Diagnosis And Antiviral Therapy Of Human Herpesvirus 8 Infection

The first disease associated with human herpesvirus 8 (HHV-8) infection was Kaposi sarcoma (KS). Subsequently, several other conditions, such as primary effusion lymphoma (PEL, also known as body cavity based lymphoma) and Castleman’s disease (CD), w. The diagnoses of KS, multicentric Castlemans disease and primary effusion lymphoma depend on cytologic and immunologic cell markers, as well as histology. Antiviral therapy for HHV-8 infection in pregnancy is not recommended (AIII). Multicentric Castleman’s Disease. Many HHV-8-lytic infected cells are found in multicentric Castleman’s disease lesions, suggesting that this disease could be more responsive to antiviral therapy (19, 31).

Diagnosis And Antiviral Therapy Of Human Herpesvirus 8 Infection 2Means of diagnosis of human herpesvirus 8 infection. Long-term efficacy on Kaposi’s sarcoma of highly active antiretroviral therapy in a cohort of HIV-positive patients. As HHV-8 cannot be cultivated readily, the diagnosis of infection with HHV-8 relies either on assessing the antibody response to infection or on detecting viral nucleic acid in clinical specimens. (130,131) Treatment of HHV-8-related disease with antivirals has met with mixed success. In parts of Africa, HHV-8 has infected over half the adult population. Treatment is experimental at this time, but anti-viral drugs or beta interferon may be tried.

Most recently, new HHV-8 infection among gay men has been associated with an HIV-positive partner, rather than any specific sexual practice, and use of amyl nitrate. Differential reduction of human herpesvirus 8 oropharyngeal shedding rats with specific antiretroviral agents. Forty six HIV-1 infected individuals diagnosed with different HHV-8 associated diseases were studied 37 epidemic Kaposi’s sarcoma (KS), 3 pleural effusion lymphoma (PEL); 5 peripheral lymphadenopathies (PL); 1 Hodgkin’s lymphoma (HL); 1 non Hodgkin’s lymphoma (NHL). Study before and after Highly Active Antiretroviral Therapy, British Journal of Cancer, Vol. Combined antiretroviral therapies have reduced the incidence of Kaposi sarcoma but not MCD and PEL. A retrospective diagnosis of HHV-8 primary infection was reported: the patient presented fever, arthralgia and polyadenopathy, which may be mistaken for numerous viral primary infections 15.

Human Herpesvirus 8: Current Issues

Once the diagnosis of KS has been made, treatment is based on the subtype and the presence of localized versus systemic disease. However, with AIDS-related KS, highly active antiretroviral therapy (HAART) has been shown to prevent, or induce regression of KS. The tumor arises either when an HHV 8-infected organ is transplanted into someone who has not been exposed to the virus or when the transplant recipient already harbors pre-existing HHV 8 infection. Fortunately, the widespread use of highly active antiretroviral therapy (HAART) has reduced the number of patients who develop KS. Epidemic KS – occurrence of KS in patients infected with HIV. Definitive diagnosis is based on biopsy features with the presence of spindle cells. Herein, we describe the case of a Kenyan man diagnosed with HIV in 2000. He deferred highly active antiretroviral therapy (HAART) and remained in good health until his CD4+ count declined in 2006. KS is etiologically linked to human herpesvirus-8 (HHV-8), also known as KS-associated herpesvirus (KSHV) 8. In areas where the incidence of KS is sporadic, HHV-8 infection is acquired in adulthood and is mainly associated with sexual activity (30). Trends in HIV-1 viremia were found to be associated with the antiretroviral treatment schedule. HHV-8-infected patients had higher levels of hsCRP (median interquartile range, 3. HHV-8 DNA PCR was positive in 3 of the 6 patients during HIV infection preceding the appearance of KS and in all but 1 of 11 AIDS patients with KS.

Hiv & Aids Information

Dieases caused by HHV-8 infection include Kaposi sarcoma (KS), multicentric Castleman disease (MCD), and primary effusion lymphoma (PEL), which occur primarily in patients with HIV infection. The benefit of various antiviral treatment strategies for other HHV-8-related diseases, particularly MCD, is suggested by some reports 44,64,65,66,67,68, but not others 69, and definitive data do not exist to recommend specific therapies. Acute infection with HHV-8 and progression to KS in children may be different than in adults, and diagnosis may be overlooked. Currently, neither adult nor pediatric treatment guidelines exist. Relapse of Kaposi’s Sarcoma and HHV-8 Viremia in an HIV-infected Patient Switching from Protease Inhibitor to Integrase Inhibitor-Based Antiretroviral Therapy.